【摘要】 目的：探究尼卡地平对高血压脑出血（HICH）患者血清（sCysC）、血肌酐（Scr）、血乳酸（Lac）、血钙（Ca2+）水平的调控及急性肾损伤（AKI）的预防效果。方法：选取我院2017年1月～2018年1月收治的HICH患者150例为研究对象，按照随机数字表法分为观察组与对照组，各75例。其中对照组行乌拉地尔降压治疗，观察组行尼卡地平治疗。比较两组AKI发生率及sCysC、Scr、Lac、Ca2+水平差异，并分析sCysC、Scr、Lac、Ca2+对AKI的预测价值。 结果：治疗2周后，两组血清sCysC、Scr、Lac均呈降低趋势，Ca2+水平升高，且观察组sCysC、Scr、Lac水平低于对照组（P<0.05），Ca2+水平高于对照组（P<0.05）。150例HICH患者出现AKI 16例（10.67%），未发生AKI 134例（89.33%）。且观察组患者AKI的发生率为4.00%，低于对照组的17.33%，差异具有统计学意义（P<0.05），但两组并发症总发生率差异无统计学意义（P>0.05）。二元Logistic回归分析显示，APACHEⅡ评分、sCysC、Scr、Lac均为HICH患者AKI发生的危险因素（P<0.05），Ca2+为HICH患者AKI发生的保护因素（OR=0.016，P<0.05）。ROC曲线分析显示，血清sCysC、Scr、Lac、Ca2+水平对HICH患者AKI预后具有一定的价值（AUC=0.932、0.840、0.833、0.886）。结论：尼卡地平对HICH患者的治疗效果肯定，其可降低AKI发生率，改善患者预后；且sCysC、Scr、Lac、Ca2+水平对HICH患者AKI发生具有一定的诊断价值。

【Abstract】 Objective: To explore the effect of nicardipine on the occurrence of acute renal injury (AKI) in the treatment of hypertensive intracerebral hemorrhage (HICH) and the predictive value of serum cystatin C (sys C), serum creatinine (Scr), blood lactic acid (Lac) and blood calcium (Ca2+) on it. Methods:The HICH patients admitted in our hospital from January 2017~ January 2018 were selected as the subjects. According to the random number table method ,150 patients were divided into observation group and control group ,75 cases each. The control group was treated with uradil hypotension and the observation group with nicardipine. The incidence and sCysC、Scr、Lac、Ca2+ level of AKI between the two groups were compared, and the predictive value of sCysC、Scr、Lac、Ca2+ for AKI was analyzed.Results: After 2 weeks of treatment, Both groups showed decreased serum sCysC、Scr、Lac, Ca2+ levels rise, The sCysC、Scr、Lac level in the observation group was lower than that in the control group (P<0.05), The Ca2 level was higher than that of the control group (P<0.05). There were AKI 16 cases in 150 HICH patients (10.67%), AKI 134 cases did not occur (89.33%). And the incidence of AKI in the observation group was 4.00, Less than 17.33% in the control group, difference was statistically significant (P<0.05), However, there was no significant difference in the total incidence of complications between the two groups (P>0.05). Dual Logistic regression analysis showed, APACHEⅡ score and sCysC、Scr、Lac were risk factors for AKI in patients (P<0.05), Ca2 were protective factors (OR=0.016) in AKI, P<0.05). ROC curve analysis shows, serum sCysC、Scr、Lac、Ca2+ levels are valuable for AKI prognosis of HICH patients (AUC=0.932,0.840,0.833,0.886).. Conclusion: The therapeutic effect of nicardipine on HICH patients is certain, which can reduce the occurrence of AKI and improve the prognosis of patients, and the sCysC、Scr、Lac、Ca2+ level has certain diagnostic value for the AKI occurrence of HICH patients.