摘 要：目的：制备姜黄素-环糊精修饰的系列介孔二氧化硅固体分散体以提高难溶性药物姜黄素的溶解和体外溶出。方法：采用透射电镜观察介孔二氧化硅的形貌和孔径并测量材料的zeta电位，氮气吸附测量载体材料的孔结构参数；扫描电镜、红外分光光度仪、差式扫描量热仪检测姜黄素与介孔二氧化硅的负载情况；体外溶解和溶出实验测量固体分散体的溶出效果。结果：姜黄素以无定型的状态负载于介孔二氧化硅载体中，制成的固体分散系统可以有效地提高姜黄素的溶解和溶出。结论：姜黄素-环糊精修饰的系列介孔二氧化硅固体分散体的制备，具有改善难溶性药物口服吸收方面的价值。

Abstract: Objective: To prepare a series of mesoporous silica solid dispersions modified by cyclodextrin to improve the dissolution of curcumin. Methods: The morphology and pore diameter of carriers were observed by transmission electron microscope, and the zeta potential also was measured. Measurement of mesoporous material parameters by nitrogen adsorption. The loading of curcumin and mesoporous silica nanoparticles was detected by scanning electron microscope, infrared spectroscopy and differential scanning calorimeter. The dissolution of solid dispersions was determined by in vitro dissolution. Results: Curcumin was loaded on mesoporous silica carrier in an amorphous state, and the solid dispersion system could significantly improve the dissolution of curcumin. Conclusion: The preparation of a series of mesoporous silica - drug loading systems modified with cyclodextrin has potential value in improving the oral absorption of insoluble drugs.

内蒙古医科大学科技百万，内蒙古医科大学博士启动