[关键词]
[摘要]
结直肠癌(Colorectal cancer，CＲC)是由抑癌基因和致癌基因的突变积累导致。Kras 是原癌基因作
用于表皮生长因子(Vascular endothelial growth factor，EGFＲ)的下游，通过小鼠肉瘤病毒癌基因同源基因B 1(vraf
murine sarcoma viral oncogene homolog B1，BＲAF) 传递信号，触发促分裂原活化的蛋白激酶(mitogenactivated
protein kinase，MAPK)通路，诱导细胞增殖，阻止细胞凋亡，引起了55% ～ 60%的CＲC．因此，Kras 基因的突变与
CＲC 的发生、发展、预后、及其药物治疗与放射治疗有着密不可分的联系，本文对CＲC 中Kras 基因表达与放射治
疗的研究进展进行系统的综述。
[Key word]
[Abstract]
More and more experiments confirmed that，Colorectal cancer is caused by the accumulation
of mutations in tumor suppressor genes and oncogenes． Kras is proto － oncogene acting on the
downstream of EGFＲ． The signal is transmitted by BＲAF，which triggers the MAPK pathway，inducing
cell proliferation，Preventing apoptosis and causing 55%－60% of CＲC．Therefore，the mutation of Kras
is closely related to the occurrence，development and prognosis of CＲC，as well as drug therapy and
radiotherapy．It has become an urgent matter to study CＲC in depth． In this article，I will review systematically
the research progress of Kras’expression and radiotherapy in CＲC．
[中图分类号]
Ｒ739．9
[基金项目]
收稿日期: 2018－03－01;修回日期: 2018－08－13
基金项目: 科技厅应用技术与开发项目(2015)
作者简介: 张薇(1993－)，女，内蒙古医科大学2017 级在读硕士研究生。
通讯作者: 孙晓革，副主任医师，硕士研究生导师，Email:sunxiaoge789@ 126． com 内蒙古医科大学附属医院放疗科，
010050
