目的: 探讨蒙古族人群同型半胱氨酸( Hcy) 及其代谢酶基因多态性与原发性高血压的关系。方法:
在蒙古族人群中，选择原发性高血压病人165 例( 高血压病组) ，血压正常者150 例( 对照组) ，应用聚合酶链反
应－限制性片断长度多态性方法( PCR－RFLP) ，检测两组甲硫氨酸合酶( MS) A 2756 G 多态位点的基因型; 采用
酶标免疫吸附检测法检测血浆Hcy 的水平。结果: 高血压组与对照组相比，血浆Hcy 水平明显增高; 且在高血压
组和对照组中，血浆Hcy 水平有明显的性别差异，男性明显高于女性( P＜0．05) 。两组间甲硫氨酸合酶( MS) A
2756 G 多态位点的基因型和等位基因频率分布无明显差异( P＞0．05) 。结论: 甲硫氨酸合酶( MS) A 2756 G 位点
的多态性与蒙古族人群原发性高血压的发生无明显的相关性; 血浆Hcy 的水平增高可能是蒙古族人群原发性高
血压发生的危险因素之一。

Objective: To investigate the relationship between the plasm homocysteine( Hcy) level
as well as methionine synthase A 2756 G( MS A 2756 G) polymorphisms and essential hypertension in
Mongolians．Methods: A total of 165 Mongolian pations with essential hypertension( Mongolian hypertension
group ) and 150 Mongolian normal controls ( control group ) were detected the gene
polymorphisms of methionine synthase A 2756 G by polymerase chain reaction － restriction fragment
length polymorphism technique．The level of plasma Hcy was measured by enzymoimmunoassay．Result:
The plasma Hcy ’s lever in hypertension group was significantly higer than that in control group( P＜
0．05) ; and in the both of the hypertension group and the control group， the lever of the plasma Hcy was
different in sex．The males’level was higer than the females( P＜0．05) ．The distribution of genotypic
and allele frequencies had no significant difference between the two groups( P ＞ 0．05) ．Conclusion:
There was probably no relation between MS A 2765 G genetic polymorphism and essential hypertension
in Mongolians．Higher lever of the plasma Hcy may be the one of the risk factors in the Mongolian hypertensions．

R544．1

 收稿日期: 2016－04－11; 修回日期: 2016－07－28
基金项目: 内蒙古自治区自然科学基金( 2012MS11109)
作者简介: 贾海玉( 1971－) ，女，内蒙古医科大学附属医院干保A 区主任医师，医学硕士。