[关键词]
[摘要]
近年来随着急性心肌梗死发病率的不断增高,促进了溶栓、经皮穿刺冠状动脉介入治疗和冠状动脉
旁路移植术( CABG) 等再灌注疗法的广泛开展,由缺血/再灌注损伤( ischemia /reperfusion injury,IRI) 引起的心脏
损伤日益受到重视。因此,研究减轻心肌缺血/再灌注损伤安全、有效的方法对防治心脏疾病具有重大的价值和
意义。近期国内外很多研究发现心肌缺血后适应( ischemic postconditioning,IPOC) 及Toll 样受体( Toll like receptor,
TRL) 在心肌缺血再灌注损伤中起重要作用,本文对此进行综述。
[Key word]
[Abstract]
In recent years, the thrombolysis,percutaneous coronary intervention and coronary artery
bypass grafting( CABG) and other reperfusion therapy are widely developing with incidence increasing
of acute myocardial infarction. Heart damage induced by the ischemia /reperfusion injury ( ischemia /
reperfusion injury, IRI) is increasingly concerned. Therefore, the study of safe and effective method in
reducing myocardial ischemia /reperfusion injury has great value and significance in the prevention of
heart disease. Recently many domestic and foreign researches found that ischemic postconditioning
( IPOC) and toll-like receptors( Toll like receptor,TRL) play important role in myocardial ischemiareperfusion
injury.
[中图分类号]
R541
[基金项目]
收稿日期: 2014-04-18; 修回日期: 2014-06-10
基金项目: 内蒙古高教厅: NJZZ12140; 内蒙自然科学: 2012MS1179
作者简介: 王妮妮( 1981-) ,女,内蒙古医科大学2011 级在读硕士研究生。
通讯作者: 王悦喜,教授,主任医师,硕士研究生导师,E-mail:
wangyuexi2@163. com 内蒙古医科大学附属医院心内科,
010050